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Therapeutic drug delivery agents being compounds containing resonators that facilitate the delivery of pharmaceutical preparations and monitoring thereof for use in connection with medical ultrasound apparatus to facilitate the lowering of the blood brain barrier; Therapeutic drug delivery agents being compounds containing resonators that facilitate the delivery of pharmaceutical preparations and monitoring thereof for use in connection with medical ultrasound apparatus to facilitate the disruption of the blood brain barrier; Therapeutic drug delivery agents being compounds containing resonators that facilitate the delivery of pharmaceutical preparations and monitoring thereof for use in connection with medical ultrasound apparatus to increase the permeability of the blood brain barrier; Therapeutic drug delivery agents being compounds containing resonators that facilitate the delivery of pharmaceutical preparations and monitoring thereof to be used in connection with ultrasound apparatus for therapeutic and diagnostic medical procedures in the fields of neurology, oncology, gynecology and urology; Therapeutic drug delivery agents being compounds containing resonators that facilitate the delivery of pharmaceutical preparations and monitoring thereof to be used in connection with ultrasound apparatus for therapeutic and diagnostic medical procedures with respect to central nervous system disorders, neurodegenerative disease, neuro-oncological disease, neuropsychiatric and behavioral disorders, movement disorders, prostate cancer, uterine fibroids and bone metastases; Therapeutic drug delivery agents being compounds containing resonators that facilitate the delivery of pharmaceutical preparations and monitoring thereof to be used in connection with ultrasound apparatus for therapeutic and diagnostic medical procedures, namely, for use in the ablation of tissue, sonication of tissue, and disruption of the blood brain barrier