clinical pharmacologic studies and investigations; namely, safety, tolerance and pharmacokinetic studies of single dose, multiple dose and dose ranging studies; short-term safety, efficacy and pharmacodynamic studies of both normal volunteers and target patient populations; long-term safety, efficacy, dose optimization and drug interaction; and promotional, drug surveillance and epidemiological studies

'clinic':1 'dose':14,16,18,42 'drug':45,49 'efficaci':25,41 'epidemiolog':52 'interact':46 'investig':5 'long':38 'long-term':37 'multipl':15 'name':6 'normal':31 'optim':43 'patient':35 'pharmacodynam':27 'pharmacokinet':10 'pharmacolog':2 'popul':36 'promot':48 'rang':19 'safeti':7,24,40 'short':22 'short-term':21 'singl':13 'studi':3,11,20,28,53 'surveil':50 'target':34 'term':23,39 'toler':8 'volunt':32

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