Metabolism assay used to stratify patients in trials; small molecules intended to target multiple nodes in NAD synthesis pathways identify and characterize altered states of NAD metabolism; drugs and therapies that target NAD metabolism defects in cancer

'alter':23 'assay':2 'cancer':37 'character':22 'defect':35 'drug':28 'identifi':20 'intend':11 'metabol':1,27,34 'molecul':10 'multipl':14 'nad':17,26,33 'node':15 'pathway':19 'patient':6 'small':9 'state':24 'stratifi':5 'synthesi':18 'target':13,32 'therapi':30 'trial':8 'use':3

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